About Functional Dyspepsia (FD) or Meal - Triggered Indigestion

It is often a remitting-relapsing functional bowel disorder with no known cause. FD is a common, under-diagnosed2, and under-managed disorder in the upper belly. FD is often described as non-ulcer dyspepsia.

Functional Dyspepsia is the presence of symptoms that originate in the gastro-duodenal region in the absence of any systemic disease that could explain the symptoms.

It is estimated that 60-70% of patients with FD are hypersensitive to nutrients3. 79% of persons with dyspepsia report that their symptoms are aggravated by the ingestion of a meal4.

Looking at only the Rome IV criteria, FD symptoms include epigastric pain or discomfort, postprandial fullness, and early satiety (cannot finish a normal sized meal) within the last 3 months, with symptom onset at least 6 months earlier. Other common symptoms include postprandial nausea, belching and abdominal bloating.


79% of individuals with dyspepsia report that their symptoms are aggravated by the ingestion of a meal4.

The Distinctive Nutritional Requirements for People with FD

People with FD often do not eat regularly or normally, which may affect their normal intake of nutrients. Also, their digestion of food and absorption of nutrients may be affected due to motility disturbances in the GI tract. Patients with FD have been known to experience weight loss because of reduced food intake or retention of food5.

The inflammatory cascades6 (e.g., eosinophils in the duodena)7 related to FD are associated with permeability dysfunction, which, in turn, affects the digestion and absorption of nutrients.

Deficiency of folate and B12 has been shown in FD. There is an association of other micronutrient deficiencies and FD8.

There is increasing evidence that impaired mucosal defense mechanisms are implicated in the pathogenesis of functional gastrointestinal disorders (FGIDs), allowing inappropriate immune activation9,10.

More recently, perturbations of GI microbiota, altered mucosal permeability and abnormal mucosal defense mechanisms have been implicated in the pathogenesis of some FGIDs6,11-15.

Dietary modification alone, as a management strategy, has had mixed success. Fiber is helpful. Exclusionary diets16 may help in the short term but also may lead to nutritional imbalances and adherence issues in the long-term. Diet alone does not address the complex disruptions of the upper belly17.

To effectively manage FD, it is important to help normalize the gut mucosal barrier dysfunction and its associated localized, reversible, low-grade inflammation7.

Now, physicians increasingly use medical foods, such as FDgard®, to help normalize the digestion and absorption of food nutrients and to help manage FD symptoms.

FDgard® is specially formulated to meet the distinctive nutritional requirements of FD that cannot be met with dietary modification, alone. FDgard® is designed to supply microspheres of caraway oil and l-Menthol, along with fiber and amino acids (from gelatin protein), to the upper belly. The anti-inflammatory18,19, anti-spasmodic20,21, and visceral analgesic22,23, and carminative (anti-gas)24,25 properties of caraway oil and peppermint oil (primary component: l-Menthol) help toward normalizing the digestion and absorption of food nutrients, and to manage the symptoms of FD.

By improving gut health in the first place, FDgard® can help avoid nutritional problems downstream.


Dr. Arai

“What I like about FDgard® is it’s very safe, very easy to access...It’s very effective, and I find that it works early on.”

Dr. Shanmugam

“FDgard® [has] very minimal side effects and is easily accessible over the counter.”


“One will do anything to feel better, so my husband and I went to CVS/pharmacy and luckily found one remaining box on the shelf, I bought it, took it that afternoon and again the next morning. To my surprise and amazement, I felt great within a short time, and continued feeling wonderful.”

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